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Affinity maturation during the
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ANTIBODY REPERTOIRES AND PATHOGEN
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A significant proportion of
Mutants must be generated and selected in a step-wise fashion during the germinal center reaction
Affinity maturation during the germinal center reaction
One-pass selection model of the germinal center reaction
Basic model
Amplification of high affinity cells in the memory population is a logarithmic function of their selection coefficient
Implications for affinity maturation in the germinal centers
Mihaela Oprea
1999-04-11
