Antibody repertoires and pathogen recognition:  The role of germline diversity and somatic hypermutation.

          The immune system

           Structure of the talk

           Recognition of pathogens

           Questions

          Evolution of immune receptor libraries

                    Fitness

                    Scaling result

                    Strategies

                    Conclusions
 

           Plasticity of immunoglobulin genes under somatic hypermutation

                    What is somatic hypermutation?

                    How can affinity maturation be efficient?

                    The structure of an antibody molecule

                    CDR targeting

                    Approach

                    Scatter plots

                    What accounts for CDR-FR mutability difference?

                    Individual sequence results

                    What about non-immunoglobulin genes?

                    Mutability is correlated with A/T content

                    Conclusions
 

            Mutation rate estimation

                    Basic approach
 

            Acknowledgements