Mihaela L. Oprea
    1704/B Llano St. #135
    Santa Fe, NM 87505
    Phone: (505)466-9197
    email: mihaela@cs.unm.edu
    Web URL: http://www.cs.unm.edu/~mihaela

    Job Objective:

    Software Engineer/Designer in the area of Object Oriented Programming/Simulation.

    Education:

    M.S. in Computer Science from the University of New Mexico, Albuquerque, New Mexico, July 1996.

    M.D. from the University of Medicine and Pharmacy, Timisoara, Romania, September 1992.

    Current Job:

    08/95- : Research assistant in the Computer Science Department of the University of New Mexico, Albuquerque, involved in developing and simulating models of immunological phenomena, such as somatic hypermutation and affinity maturation. This project is done in association with the Theoretical Biology Group of the Los Alamos National Laboratory, advisor: Alan Perelson.

    Work Experience:

    Most of the work that I have done so far consists in developing mathematical models of biological processes and building the software to perform the numerical simulations.

    05/95 - 08/95: Research associate at the Santa Fe Institute involved in modeling primary antibody responses to T cell - dependent antigens.

    08/94 - 05/95: Teaching assistant and instructor for undergraduate computer science classes teaching C++ and data structures.

    06/93 - 08/94: Graduate research assistant in the Theoretical Biology Group of the Los Alamos National Laboratory, modeling the primary antibody response to T cell - dependent antigens.

    02/93 - 06/93: Graduate research assistant at the Santa Fe Institute, working on a model of idiotypic networks.

    Computer Skills:

    The simulation software that I wrote is C++ and C. Also familiar with Prolog, awk, html. Limited exposure to Tcl/Tk, BASIC, FORTRAN, Scheme.

    Operating Systems familiar with: SunOS, IBM AIX, Solaris, Linux.

    Projects worked on:

      1. Building a compiler for a subset of the C language, and using it to analyze the potential for compiler-introduced object code variability.
      2. Implementing the self-organizing map model for concept acquisition described in Schyns, 1991 (Schyns, P.G. A modular neural network model of concept acquisition. Cognitive Science 15:461, 1991).
      3. Setting up a httpd.

    Courses taken:

    Advanced Compiler Construction, Complexity Theory, Automated Reasoning, Algorithm Heuristics, Cognitive Science, Statistical Inference, Geometric and Probabilistic Methods, Operating Systems.

    Publications:

    Oprea, M. and Perelson, A. S. (1996). Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts (submitted).
    Oprea, M. and Perelson, A. S. (1996). Exploring the mechanisms of primary antibody responses to T cell-dependent antigens. Journal of Theoretical Biology 181:215-236.
    Weisbuch, G. and Oprea, M. (1994). Capacity of a model immune network. Bulletin of Mathematical Biology 56:899-921.