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- Undergraduate Education:
- B.S. in Chemistry, University of Vienna,
Austria in 1986
- B.S. in Astronomy,
University of Vienna, Austria in 1989
M.S. in Chemistry, Inst. of Theor.
Chem., Univ. of Vienna, Austria in 1990:
- "Dynamics of Autocatalytic Reaction-Mutation-Networks"
Ph.D. in Science, Theor.
Biochem. Group, Univ. of Vienna, Austria in 1993:
- "Chaotic Behavior of Reaction Networks"
University of Technology, Vienna, Austria, April 1993 - Aug. 1993
- Institute of Molecular
Biotechnology (IMB), Jena, Germany,
- Sept. 1993 - March 1994
Group Leader "Dynamics of Molecular Evolutionary Processes"
Department "Molecular Evolutionary Biology" at the IMB,
- April 1994 - Sept. 1997
Research Associate at the
University of Illinois at
Urbana-Champaign, Nov. 1997 - Oct. 1999
Staff Member at the
Los Alamos National Laboratory
Bioinformatics Team Leader, Manager of the
STD Database, Nov.
1999 - Oct. 2001
Complex Biosystems, Nov. 2001 -
- Santa Fe Institute,
Santa Fe, NM, Oct. 1995
- Santa Fe Institute, Santa Fe, NM, July 1997
for Theoretical Biology
Humboldt University, Berlin, Germany, Oct. 1997
Systems Biology / Network Genomics:
Comparative Network Analysis
- This research facilitates detailed information of completely
- sequenced microbial genomes. Here annotated functional genes are
- embedded in a metabolic network. For this purpose I developed a
- method that that extends conventional phylogenetic analysis
- of individual enzymes in different organisms to the organisms'
- metabolic networks (FORS99B).
- Recent studies include the identification of expressed
- sub-networks in cellular networks of M. tuberculosis. Metabolic
- network data is combined with protein-protein interaction
- information and genome context data to reconstruct a cellular
- network. Together with gene-expression information in combination
- of graph-theoretical approaches particular sub-networks are
- identified that are cellular responders to the experimental
- conditions measured in the gene-expression experiment.
- In addition to network studies gene context, such as
- co-occurring genes, gene-clusters, gene-fusion events and
- operon conservation has been employed for high-level annotation
- and analysis of genomes. Of special interest is the close
- relationship between operon-conservation and network-similarity
- that I have studied in the case of the tryptophan/serine
- biosynthesis network (FORS2001).
Theory of Molecular Evolution:
Evolution of Interaction:
- Describing dynamics of evolving biopolymers, e.g. as in experiments
- related to irrational drug design.
- Critical parameters such as an optimal error-rate and a phenotypic
- error-threshold are observed.
- Exploration of (large) reaction networks by a
population with distinct,
- partly neutral, genotype -- phenotype relationsship.
- Evolution towards higher organization; stability of complex organization.
- Development of genetic compartimentation; emergence of individuality.
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